New ‘munchies’ study reveals the brain changes behind the appetite effects of cannabis

first_imgPinterest New research on how cannabis use alters eating behavior could lead to treatments for appetite loss in chronic illness, according to experts at Washington State University. Using a new procedure to dose lab rats with cannabis vapor, the researchers found how the drug triggers hunger hormones.They also identified specific brain regions that shift to ‘hungry’ mode while under the influence, according to a report they shared this week at the Society for the Study of Ingestive Behavior, an international meeting of scientific experts on eating.“We all know cannabis use affects appetite, but until recently we’ve actually understood very little about how or why,” explained Jon Davis, Ph.D., researcher in the Department of Integrative Physiology and Neurosciences at Washington State. “By studying exposure to cannabis plant matter, the most widely consumed form, we’re finding genetic and physiological events in the body that allow cannabis to turn eating behavior on or off.” Email LinkedIn Sharecenter_img Share on Twitter Share on Facebook A recent wave of cannabis legalization for both medical and recreational purposes has stimulated research on its therapeutic potential. A family of compounds called cannabinoids, particularly delta-9 tetrahydrocannabinol (THC), are responsible for its psychological effects. The ability of THC to stimulate appetite is valuable since many illnesses cause extreme appetite loss which reduces quality of life and slows recovery.For these new studies the scientists designed a vapor exposure system to mimic how people often consume cannabis. This allowed precise control of dosage while rats’ meals were closely monitored throughout the day. Brief exposure to cannabis vapor stimulated a meal even when rats had recently eaten, suggesting that inhaling cannabis tricks appetite circuits in the brain into hunger mode.“We found that cannabis exposure caused more frequent, small meals,” stated Davis. “But there’s a delay before it takes effect.” That delay provided a clue to how the drug may act. Ordinarily, when the stomach is empty it releases a hormone called ghrelin, a message to the brain that it’s time to look for food. The researchers found that the cannabis dose triggered a ghrelin surge. When they gave a second drug which prevented the ghrelin surge, cannabis no longer triggered eating. They also found changes in how the brain responds to the message. In small region of the hypothalamus responsible for sensing ghrelin, cannabis changed the genetic activity of brain cells that respond to the hormone.The researchers are optimistic that deciphering that ways cannabis acts in the body to alter appetite can lead to new treatments for illness-induced anorexia. Severe appetite loss is a common symptom of many chronic illnesses, and is especially problematic in cancer, HIV/AIDS, heart disease, and some metabolic disorders. A targeted treatment that offers the beneficial effects on appetite without the broader effects on the mind and body could increase quality of life and speed recovery.last_img read more

Bremen Express Loses Unknown Number of Containers at Sea

first_imgAn undisclosed number of containers fell from the 8,750 TEU containership Bremen Express “for reasons yet to be determined,” according to German shipping firm Hapag-Lloyd.The vessel experienced rolling during a repair stop on the Atlantic earlier this week while it was sailing from Norfolk, US.Built in 2008, the boxship, which operates in the CEC service was located roughly 1,400 nautical miles west of Europe when the incident occurred.The 336-meter-long Bremen Express was able to continue sailing after reporting the loss of containers to the responsible authorities.Hapag-Lloyd said that the ship will call at a port in the Mediterranean in order to be inspected before passing through the Suez Canal on its journey to Asia.According to AIS data provided by MarineTraffic, the 103,567 dwt vessel is currently stopped at the Port of Tangier Med, Morocco.The company said that there were no reports of injuries following the incident.last_img read more

Founder of Cool Moose Party in Rhode Island dies at 58

first_imgPROVIDENCE, R.I. | Cool Moose Party founder Robert Healey, a legendary local political figure who ran for lieutenant governor on a platform of abolishing the position and who spent $36 on a gubernatorial campaign while capturing 21 percent of the vote, has died. He was 58.Known for his long-flowing beard and unconventional campaigns, Healey was an attorney who ran for either governor or lieutenant governor seven times from 1986 until 2014. He founded the Cool Moose Party in 1994 as an alternative to the two-party system that dominated state and national politics.FILE – This Oct. 30, 2006 file photo shows Robert Healey at an anti-casino rally in Warwick, R.I. Healey, who founded the Cool Moose Party and made multiple attempts to seek statewide office in Rhode Island, died Sunday night, March 20, 2016. He was 58. (Connie Grosch/The Providence Journal via AP, File)Healey was found dead Sunday night in his Barrington home, according to June Sager Speakman, president of the Barrington Town Council, and Police Chief John LaCross. A friend looking for Healey found him lying in his bed, LaCross said.The state medical examiner’s office said it is investigating the death.Healey never won a statewide election, but his quirky, anti-establishment positions frequently earned him a large minority of votes. He ran five times on the Cool Moose ticket, once as an independent and once as the Moderate Party candidate.He ran for lieutenant governor in 2010, vowing to abolish the position of lieutenant governor. He came in second with 39 percent of the votes.In his 2014 campaign for governor, spending just $35.31 on office supplies and 98 cents on postage, he once again surprised experts by garnering 21 percent in a three-way gubernatorial race, losing to Democrat Gina Raimondo.“Our outstanding performance demonstrated that people were dissatisfied with the system,” Healey wrote on his campaign blog after the election. “The real story is that there are just too many out there still willing to play the party politics game. Together we shocked the system.”Raimondo was among several members of Rhode Island’s political establishment who expressed their sadness Monday at Healey’s death.“I will miss his passion and willingness to engage in spirited debate,” she said.Healey served on the Warren School Committee before attempting his first gubernatorial run in 1986.When his fledging Cool Moose Party was coalescing in the early 1990s, Healey held a convention that attracted a wide assortment of “people in combat fatigues, guns rights people, socialists and Green Party people. It was just bonkers,” said former party activist Algernon D’Ammassa. “It ended up being a party that had a very libertarian slant.”Healey’s irreverent persona and unusual appearance helped attract media attention and appealed to disaffected voters, said D’Ammassa, an actor and playwright who now teaches at New Mexico State University.“He was prickly. A kind of mercurial guy. But also very benevolent and encouraging of people to participate in their politics,” D’Ammassa said.Healey was also an entrepreneur who at one time owned a cheese shop and other businesses. He was a fixture in the small towns of Rhode Island’s East Bay region where he lived for many decades.Speakman, who lived in the same Barrington neighborhood as Healey, sometimes invited him to speak at her political science classes at Roger Williams University.“He gave my students a sense that anyone could run for elected office,” she said. “He showed this is a system that’s open to everyone, and he held our feet to the fire.”last_img read more

Calvin Abueva returns to Phoenix practice despite indefinite ban

first_imgDon’t miss out on the latest news and information. LOOK: Chilling Adventures of Sabrina Part 3 takes you straight to hell with a Music Video and First Look-Images LATEST STORIES Negros Occidental gov’t, church call for prayers for safety of Taal evacuees Abueva was suspended indefinitely on June 4 after a physical altercation with TNT big man Terrence Jones in the Commissioner’s Cup. He also exchanged verbal jabs with a female fan that turned out to be Bobby Ray Parks Jr.’s girlfriend.The PBA also slapped with him a total of P70,000 fine, P50,000 on his clothesline of Jones and P20,000 for the verbal altercation.Abueva’s life then got crazier during his suspension when he and his wife Sam publicly expressed their marital problems and the 6-foot-2 forward was seen playing in a non-sanctioned tournament.Sports Related Videospowered by AdSparcRead Next ‘People evacuated on their own’ Palace ‘not bothered’ by Trump OK on US ban vs De Lima jailers PLAY LIST 02:31Palace ‘not bothered’ by Trump OK on US ban vs De Lima jailers00:50Trending Articles00:50Trending Articles01:04Daybreak as smoke, ash billows from Taal volcano01:05Poor visibility, nakaapekto sa maraming lugar sa Batangas03:028,000 pulis sa Region 4-A, tuloy ang trabaho03:57Phivolcs, nahihirapan sa komunikasyon sa Taal01:04Sold-out: Stores run out of face masks after Taal spews ash01:45Iran police shoot at those protesting plane shootdown Francis Kong, Jason Magbanua headline ‘The School for the Passionate, New Bold U 2020’ View comments Phoenix head coach Louie Alas, who got reunited with Abueva at Upper Deck Sports Center, said the return of their beleaguered forward, in practice at least, was “super good news.”“At least he can now see the light at the end of the tunnel unlike before when all of us were confused,” said Alas in Filipino. “It’s a very good development, hopefully this will the suspension would be lifted soon.”Shaking off the rust. 👀💥#CalvinAbueva | #FightToThePhoenix— Phoenix Pulse Fuel Masters (@fuelmasters) September 26, 2019ADVERTISEMENTcenter_img Huge sinkhole swallows bus, kills six in China MOST READ LOOK: Taal Volcano island 2 days after eruption Abueva also conducted basketball clinics to help his cause. No need to wear face masks in Metro Manila, says scientist Taal Volcano eruption: House to develop rehab plan for Batangas, Cavite, Laguna THIS IS NOT A THROWBACK: The Beast has returned to practice today. #FightToThePhoenix— Phoenix Pulse Fuel Masters (@fuelmasters) September 26, 2019MANILA, Philippines—Calvin Abueva is getting a new chance at life after PBA Commissioner Willie Marcial allowed him to join Phoenix’ practices starting Thursday despite being under indefinite suspension.FEATURED STORIESSPORTSAndray Blatche has high praise for teammate Kai SottoSPORTSBig differenceSPORTSAlmazan status stays uncertain ahead of Game 4As per the league’s official website, Abueva sat down with Marcial on Sept. 16 and asked if he could join the Fuel Masters’ practices even if his suspension is still in effect and the commissioner granted the polarizing forward’s request.ADVERTISEMENT LVPI hopes to see Valdez, other PVL stars suit up in Asean Grand Prix 2nd leglast_img read more