For the five-year follow up, structured psychiatric interviews were conducted for 68 of the original participants with bipolar disorder – 37 being lost to follow up – and 81 control group members. Among those in the bipolar group, 23 no longer met criteria for the disorder, 36 still were experience active symptoms and 9 had symptoms that did not meet full criteria. During the five years since the original study, more members of the bipolar group developed new cases of substance use disorder than did controls, leading to an overall incidence rate of 49 percent versus 26 percent.While controlling for the presence of other disorders – including attention-deficit hyperactivity disorder (ADHD) or conduct disorder – did not affect the bipolar-associated risk in the original study, the new analysis found that controlling for conduct disorder caused the increased levels of substance use disorder to disappear. That result suggests that co-occurring conduct disorder plays a significant role in the risk associated with bipolar disorder.“We were surprised to find that conduct disorder, but not ADHD, played such a large role in mediating the increased risk of substance use disorder among those with bipolar disorder,” says Wilens, who is an associate professor of Psychiatry at Harvard Medical School. “While this might be result of having only a few participants with bipolar disorder alone, it may be that it is the presence of conduct disorder that drives substance use disorder as adolescents with bipolar disorder become young adults. Since symptoms of bipolar disorder usually appear before substance use disorder develops, clinicians following youth with bipolar disorder should carefully monitor for cigarette smoking and substance use, along with treating bipolar symptoms.”Wilens and his colleagues are also analyzing a subgroup of study participants who received detailed brain imaging in an effort to understand the brain circuitry involved in these disorders and their interaction. They also plan to investigate factors underlying the persistence of bipolar disorder and the impact of treatment on the incidence of smoking and substance use disorder. Share on Facebook Share on Twitter Pinterest LinkedIn Share Email A follow up to a previous study finding an association between adolescent bipolar disorder and the incidence of cigarette smoking and substance use disorder finds that risk was even greater five years later, particularly among those with persistent bipolar symptoms. The report from a team of Massachusetts General Hospital (MGH) investigators, published in the Journal of Clinical Psychiatry, also finds evidence that the presence of conduct disorder, in combination with bipolar disorder, may be the strongest influence on the risk of smoking and substance use disorder.“We also made another interesting finding – that those originally diagnosed with bipolar disorder who continued to have symptoms five years later were at an even higher risk for cigarette smoking and substance use disorder than those whose symptoms were reduced either because of remission from bipolar disorder or from treatment,” says Timothy Wilens, MD, chief of Child and Adolescent Psychiatry at Mass. General Hospital for Children and co-director of the MGH Center for Addiction Medicine, who led both studies. “Both those with active symptoms and those whose symptoms had improved were at greater risk than our control group.The original study, published in the June 2008 issue of Drug and Alcohol Dependence, analyzed extensive data – including family histories, information from primary care physicians and the results of structured psychiatric interviews – on 105 early adolescents diagnosed with bipolar disorder and a control group of 98 with no mood disorders. Among those participants, with an average age of 14, the rate of substance use disorder among those with bipolar disorder was 34 percent, while it was only 4 percent in controls. The risk for smoking was 22 percent for those with bipolar disorder and 4 percent for controls.
COUNTY News:Road Closures: Atomic Man Duathlon Fat Man and Little Boy Races in White Rock Saturday MorningThe Atomic Man Duathlon Fat Man race begins at 8 a.m. and the Little Boy Race begins at 8:20 a.m. The races should end by 12:30 p.m. The intersection of Grand Canyon at N.M. 4 (at Pajarito Road) will be manned by police officers.The Foot Race route will begin at Pinon Elementary School and head down Grand Canyon to N.M. 4 to Piedra Loop and back to Pinon Elementary. The Bike race route is similar with the exception they will loop around back to the school and then back to N.M. 4 to Bandelier and back to Pinon Elementary School. Police officers will assist at all turn arounds. The road will be closed at Sherwood Boulevard and Grand Canyon on the school side. It also will be closed at Grand Canyon Drive at Sierra Vista Drive.Drivers are urged to follow all traffic devices, slow down and watch for bikers and pedestrians. Natural Gas Purging As Part Of N.M. 502 Roundabout Project Tuesday And Thursday As part of the N.M. 502 Road Reconstruction Project, Parker Construction will be tying in a new section of gas line at the DP Road/Trinity Drive intersection. Gas and air will be purged from the line several times between the hours of 5 a.m. and noon Tuesday, Sept. 24 and again Thursday, Sept. 26. During the purging operation, citizens may smell natural gas and hear loud noises usually associated with the controlled release of gas from the pipe. Vehicle traffic may be stopped for short periods of time to minimize any potential sources of ignition. Purging is necessary to safely release gas and air out of the line and into the atmosphere to safely pressurize the new system. The procedure is performed under strict federal regulatory requirements and is safe. Diamond Drive Paving Construction is nearly complete with minor clean-up work Monday through Wednesday. Expect periodic lane drops as the contractor removes plates in the roadway and takes care of general wrap up and clean-up activities. White Rock Crack Sealing Project GM Emulsion continues crack sealing roads in White Rock and expect to be working on Bryce Avenue this week. Crews are working 8:30 a.m. to 6 p.m. daily. The contractor will set up flagging operations to allow traffic flow. Weather permitting, work should be completed by Sept. 30. The contractor will then return in mid-October to fog seal the same locations. Those residences and businesses impacted by the crack sealing work will receive information with daily schedules, coordination instructions and contact information.Questions on the above projects? E-mail [email protected], or call 505.662.8150.Other road construction projects:N.M. 502 Roundabout and Road Reconstruction (NMDOT project)See special natural gas purging alert above for Tuesday, Sept. 24 and Thursday, Sept. 26. Otherwise, no change from last week’s report. Eastbound N.M. 502 traffic detours onto 4th Street and Central Avenue. After a full stop, motorists turn right (east) and travel through the construction zone to continue east bound out of Los Alamos on N.M 502. Westbound N.M 502 traffic entering Los Alamos and approaching the roundabout construction zone detours onto Central Avenue then west to Knecht Street then left to return to Trinity Drive. There is only one lane of traffic in each direction on Central Avenue. Project hours are 9 a.m. to 4:30 p.m. Monday through Friday. Please slow down, use caution and expect delays in this area, especially during peak commute times.Traffic advisories from NMDOT are available on www.nmroads.com and motorists are asked to check the site for updates on this project as it proceeds.TA-21 Clean Up Project – DP Road (N3B project)No change from last week’s report. Clean-up work on the LANL TA-21 Site at the far eastern end of DP Road continues. Large trucks carrying away demolition debris containers will be exiting DP Road at an average of approximately three trucks per day. Motorists are asked to be alert for trucks exiting; use caution when entering or exiting DP Road, as this area is near the N.M. 502 Road Reconstruction project.Oppenheimer Road ExcavationMarcon Excavating, Inc continues excavating a section of road located near 557 Oppenheimer with a traffic lane shift in this area. The project timeline has been extended and it is now anticipated to wrap up by Sept. 30. Motorists are urged to drive slowly through this work zone and watch for pedestrians.
FOUR HOURS were cut from overnight journeys between the Russian and Ukrainian capitals with the launch of the Metropolitan Express on August 1. ’It is less than a year since Russia and Ukraine signed an agreement to launch a high speed passenger train between Moscow and Kyiv’, said RZD President Vladimir Yakunin at the launch in Moscow. Tracks and overhead electrification on the route have been modernised to permit speeds of up to 140 km/h, reducing the journey time from between 13 and 14h to around 91/2h.Running daily, the southbound train leaves Moscow’s Kievskaya station at 23.23 and arrives in the Ukrainian capital at 08.00 local time. Departures from Kyiv are at 20.09, arriving in Moscow at 06.39 local time.Each operator provides one trainset. The RZD set comprises seven sleeping cars, seven compartment vehicles, one luxury coach and a dining car, while the Ukrainian train has an addition sleeper in place of the luxury car.Grand Express launched a privately-operated luxury overnight train between Moscow and St Petersburg on August 3. Prices for the 9h trip range from 3150 roubles for a berth in a shared first class compartment, up to 12500 roubles for sole occupancy of a Grand de Luxe suite with toilet, shower, LCD television and Wi-Fi internet access. General Director Andrei Kudryavtsev said Grand Express had invested 1·2bn roubles in the project. nCAPTION: The Metropolitan Express (left) was officially launched at Moscow’s Kievskaya station on August 1 by Russian Transport Minister Igor Levitin (above left), RZD President Vladimir Yakunin (second left) and Mayor of Moscow Yuri Luzhkov (fourth left) Photos: RZD